Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
S. C. Griffiths, J. Tan, A. Wagner, L. L. Blazer, J. J. Adams, S. Srinivasan, S. Moghisaei, S. S. Sidhu, C. Siebold, H.-Y. H. Ho
This study determines the structure of ROR2's CRD and Kr domains, revealing a novel mechanism for WNT5A signaling and identifying the CRD's role in ROR2 function and secretion.
bioRxiv · Jul 26, 2021Biochemistry