Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1
P.-Y. Tsai, M.-S. Lee, U. Jadhav, I. Naqvi, S. Madha, A. Adler, M. Mistry, S. Naumenko, C. A. Lewis, D. S. Hitchcock, F. R. Roberts, P. DelNero, T. Hank, K. C. Honselmann, V. Morales Oyarvide, , N. Y. Kalaany
This study shows that pancreatic cancer cells can adapt to nutrient deprivation by stabilizing glutamine synthetase via mTORC1, and this adaptation is reversible.
bioRxiv · Feb 16, 2020Cancer Biology