Author

S. Madha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. A. Shivdasani· 2 shared A. Adler· 1 shared A. Giobbie-Hurder· 1 shared A. H. Maglieri· 1 shared A. Roesch· 1 shared A. Wang· 1 shared A. Y. Huang· 1 shared A. Zaremba· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

R. A. Shivdasani

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Author profile →

3 papers

Recent·Most cited

Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

G. Tarantino, C. A. Ricker, A. Wang, W. Ge, T. J. Aprati, A. Y. Huang, S. Madha, J. Chen, Y. Shi, M. Glettig, D. T. Frederick, S. Freeman, M. M. Holovatska, M. P. Manos, L. Zimmer, , D. Liu

This study identifies genomic heterogeneity and ploidy as markers of intrinsic resistance to PD-1 blockade in metastatic melanoma, with a decision tree model predicting resistance with high confidence.

Science Advances · Nov 29, 2024Peer-reviewedCancer Biology

Defining the structure, signals, and cellular elements of the gastric mesenchymal niche

E. Manieri, G. Tie, D. Seruggia, S. Madha, A. H. Maglieri, K. Huang, Y. Fujiwara, K. Zhang, S. H. Orkin, N. McCarthy, R. A. Shivdasani

The paper identifies regional subpopulations and niche properties of gastric PDGFRA+ mesenchymal cells, revealing distinct roles in supporting corpus and antral organoids.

bioRxiv · Feb 11, 2023Cell Biology

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

P.-Y. Tsai, M.-S. Lee, U. Jadhav, I. Naqvi, S. Madha, A. Adler, M. Mistry, S. Naumenko, C. A. Lewis, D. S. Hitchcock, F. R. Roberts, P. DelNero, T. Hank, K. C. Honselmann, V. Morales Oyarvide, , N. Y. Kalaany

This study shows that pancreatic cancer cells can adapt to nutrient deprivation by stabilizing glutamine synthetase via mTORC1, and this adaptation is reversible.

bioRxiv · Feb 16, 2020Cancer Biology