Cancer BiologybioRxiv
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1
P.-Y. Tsai, M.-S. Lee, U. Jadhav…·N. Y. Kalaany
This study shows that pancreatic cancer cells can adapt to nutrient deprivation by stabilizing glutamine synthetase via mTORC1, and this adaptation is reversible.
DOI 10.1073/pnas.2003014118