FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
C. Liu, M. Schönke, B. Spoorenberg, J. Lambooij, H. van der Zande, E. Zhou, M. E. Tushuizen, A.-C. Andreasson, A. Park, S. Oldham, M. Uhrbom, I. Ahlstedt, Y. Ikeda, K. Wallenius, X.-R. Peng, , P. C. Rensen
This study shows that FGF21 overexpression in the liver reduces lipotoxicity, inflammation, and fibrosis in NASH by blocking lipid influx and macrophage activation.
bioRxiv · Sep 20, 2022Pathology