A. Park

A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells

This paper develops a temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery, achieving high gene editing efficiency in human cells without triggering immune responses.

RADIF(C1orf112)-FIGNL1 Complex Regulates RAD51 Chromatin Association to Promote Viability After Replication Stress

The paper identifies RADIF and FIGNL1 as regulators of RAD51 chromatin association, showing their role in promoting viability after replication stress through proper RAD51 dynamics.

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

This study develops TAG72-CAR T cells with antigen-dependent IL-12 signaling to enhance anti-tumor activity and systemic disease targeting in ovarian cancer.

Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Cells Through Activation of Bitter Taste Receptor T2R14

This study shows lidocaine activates T2R14 in HNSCC cells, leading to apoptosis via mitochondrial depolarization, ROS production, and proteasome inhibition.

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

This study shows that FGF21 overexpression in the liver reduces lipotoxicity, inflammation, and fibrosis in NASH by blocking lipid influx and macrophage activation.

Autophagy gene-dependent intracellular immunity triggered by interferon-γ

This paper identifies new ATG genes and pathways involved in IFN-γ-induced intracellular immunity against norovirus and Toxoplasma gondii.

Application of an integrated computational antibody engineering platform to design SARS-CoV-2 neutralizers

The paper designs SARS-CoV-2 neutralizing antibodies using a computational platform to improve binding affinity and developability, and introduces trispecific formats and Fc modifications to enhance efficacy and reduce risk.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

Kinetic Modeling of West Nile Virus Fusion Indicates an Off-pathway State

The paper revises a previous simulation of WNV fusion and finds an off-pathway state is necessary, suggesting flaviviruses may share this mechanism.

Gene Expression Meta-Analysis Reveals Interferon-induced Genes

This paper uses gene set enrichment analysis to identify interferon-induced genes associated with SARS-CoV infections across human and mouse models.

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

This study shows that poly-PR and poly-GR DPR proteins inhibit ribosome peptidyl-transferase activity by blocking the polypeptide tunnel, as revealed by cryo-EM structures.

Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity

This study uses transposon mutagenesis to analyze genomic plasticity in paramyxoviruses, finding structural constraints in envelope glycoproteins and variability in genomic regions.

Alcohol increases aggression in flies

The paper identifies two pathways by which alcohol increases aggression in male flies: one through enhancing an olfactory pheromone and the other through systemic alcohol effects.

Microbiota-dependent elevation of Alcohol Dehydrogenase in Drosophila is associated with changes in alcohol-induced hyperactivity and alcohol preference

This study identifies microbiota-dependent elevation of Alcohol Dehydrogenase in Drosophila males, linked to altered alcohol-induced hyperactivity and ethanol preference.