Y. Ikeda

Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters

This study develops a 3D in vitro system to visualize tumor intravasation of CTC clusters and identifies TGF-β and activin signaling as essential for this process.

Spatiotemporal observation reveals metastatic tumor-driven vascular remodeling as a potential route to polyclonal colonization

The paper investigates extravasation mechanisms in metastatic tumors using a 3D microvessel model and time-lapse imaging, revealing vascular remodeling as a key process in polyclonal colonization.

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

Immunostimulatory effects of Bacillus coagulans SANK70258

This study evaluates the immunomodulating effects of Bacillus coagulans SANK70258, showing it induces high IFN-γ and IgA production compared to other lactic acid bacteria.

Kaempferol suppresses the activation of mast cells by modulating the expression of FcϵRI and SHIP1

This study shows kaempferol suppresses mast cell activation by reducing FcεRI surface expression and increasing SHIP1 levels, independent of transcription and translation.

Decoy Receptor Fine-tunes Cytokinin Signaling

The paper identifies a decoy receptor in plants that attenuates cytokinin signaling by binding the hormone without activating downstream pathways.

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

This study shows that FGF21 overexpression in the liver reduces lipotoxicity, inflammation, and fibrosis in NASH by blocking lipid influx and macrophage activation.

Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25 by silkworm, Bombyx mori, and its biochemical analysis.

This study expresses and purifies recombinant Pvs25 from silkworms, demonstrating its potential as a malaria transmission-blocking vaccine candidate with high immunogenicity.

Fractal scaling of C. elegans behavior is shaped by insulin signaling

This study shows insulin signaling in C. elegans regulates fractal scaling of behavior, with glucose and genetic mutants affecting the power-law to exponential transition in residence-time distribution.

Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase.

This study identifies the TRNVF motif as responsible for PI5P4Kβ's GTP binding and extended specificity to ITP and XTP, showing how its GTP preference allows it to function as a GTP sensor despite low cellular concentrations of ITP and XTP.

C. elegans episodic swimming is driven by multifractal kinetics

This study identifies multifractal kinetics in C. elegans episodic swimming and links it to PKG regulation of behavioral transitions.

Loss of CG methylation in Marchantia polymorpha causes disorganization of cell division and reveals unique DNA methylation regulatory mechanisms of non-CG methylation.

This study shows that loss of CG methylation in Marchantia polymorpha disrupts cell division and reveals unique non-CG methylation regulatory mechanisms in basal land plants.

The FACT complex is required for DNA demethylation at heterochromatin during reproduction in Arabidopsis

This study shows that the FACT complex facilitates DME-mediated DNA demethylation at heterochromatin during Arabidopsis reproduction by enabling access to GC-rich, nucleosome-dense regions.