An inability to maintain the ribonucleoprotein genomic structure is responsible for host detection of negative-sense RNA viruses
D. Blanco-Melo, B. E. Nilsson-Payant, S. Uhl, B. Escudero, S. Olschewski, P. Thibault, M. Panis, M. Rosenthal, C. Munoz-Fontela, B. Lee, B. tenOever
The paper shows that limiting nucleoprotein (NP) in negative-sense RNA viruses leads to defective genomes and triggers host interferon responses, making NP a key antiviral target.
bioRxiv · Mar 12, 2020 · PreprintMicrobiology