Author

D. Blanco-Melo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

B. E. Nilsson-Payant· 2 shared B. R. tenOever· 2 shared M. Panis· 2 shared S. Uhl· 2 shared W.-C. Liu· 2 shared A. Jiang· 1 shared A. Nurani· 1 shared B. Escudero· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

B. E. Nilsson-Payant

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Author profile →

3 papers

Recent·Most cited

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

L. Si, H. Bai, M. Rodas, W. Cao, C. Y. Oh, A. Jiang, R. Moller, D. Hoagland, K. Oishi, S. Horiuchi, S. Uhl, D. Blanco-Melo, R. A. Albrecht, W.-C. Liu, T. Jordan, , D. E. Ingber

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

bioRxiv · Apr 13, 2020 · PreprintMicrobiology

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems

D. Blanco-Melo, B. Nilsson-Payant, W.-C. Liu, R. Moeller, M. Panis, D. Sachs, R. Albrecht, B. R. tenOever

This study characterizes the host transcriptional response to SARS-CoV-2 and other respiratory viruses in multiple models, finding a unique muted response lacking certain cytokine and chemokine induction.

bioRxiv · Mar 24, 2020Microbiology

An inability to maintain the ribonucleoprotein genomic structure is responsible for host detection of negative-sense RNA viruses

D. Blanco-Melo, B. E. Nilsson-Payant, S. Uhl, B. Escudero, S. Olschewski, P. Thibault, M. Panis, M. Rosenthal, C. Munoz-Fontela, B. Lee, B. tenOever

The paper shows that limiting nucleoprotein (NP) in negative-sense RNA viruses leads to defective genomes and triggers host interferon responses, making NP a key antiviral target.

bioRxiv · Mar 12, 2020 · PreprintMicrobiology