P. Thibault

Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia

This study shows that 5-azacytidine induces endogenous retroelement transcripts in AML cells, which are degraded by autophagy and not presented as MHC-I peptides, and that autophagy inhibition enhances immune responses.

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

Transposable elements regulate thymus development and function

This study investigates the role of transposable elements in thymus development and function, showing their interactions with transcription factors and their impact on T-cell tolerance.

LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.

K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ)

BamQuery: a proteogenomic tool for the genome-wide exploration of the immunopeptidome

BamQuery quantifies MAPs from various genomic regions in bulk and single-cell RNA-seq data, revealing non-canonical sources of tumor antigens and viral peptides.

Immunological landscape of human lymphoid explants during measles virus infection

The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.

SUMO Modifies GβL and Mediates mTOR Signaling

This study identifies SUMO modification of GβL as a regulator of mTOR complex assembly and activity, showing that SUMOylation is essential for proper mTOR signaling.

SUMOylation- and GAR1-dependent regulation of dyskerin nuclear and subnuclear localization

This study identifies SUMOylation sites in dyskerin that regulate its nuclear and subnuclear localization, essential for its function in telomerase and H/ACA ribonucleoprotein complexes.

Rhes, a Striatal Enriched Protein, Regulates Post-Translational Small-Ubiquitin-like-Modifier (SUMO) Modification of Nuclear Proteins and Alters Gene Expression

This study identifies Rhes as a regulator of SUMOylation of nuclear proteins and shows its role in modulating striatal gene expression through SUMO-dependent mechanisms.

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis

This study identifies Cyclin B3 as a kinase that activates the APC/C by phosphorylating its subunits, facilitating chromosome segregation in both meiosis and mitosis.

A nitrogen source-regulated microprotein confers an alternative mechanism of G1/S transcriptional activation in budding yeast

The paper identifies NRS1, a nitrogen-responsive microprotein in budding yeast, that provides an alternative mechanism for G1/S transcriptional activation under poor nitrogen conditions.

An inability to maintain the ribonucleoprotein genomic structure is responsible for host detection of negative-sense RNA viruses

The paper shows that limiting nucleoprotein (NP) in negative-sense RNA viruses leads to defective genomes and triggers host interferon responses, making NP a key antiviral target.

Quantitative proteomics identifies novel PIAS1 protein substrates involved in cell migration and motility

The paper identifies novel PIAS1 substrates using quantitative proteomics, revealing a role for PIAS1 in cell migration via SUMOylation of Vimentin.

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.