Author

S. Othy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Jairaman· 2 shared I. Parker· 2 shared J. L. Dynes· 2 shared Q. Nie· 2 shared T. X. Dong· 2 shared A. MacLean· 1 shared A. Moshensky· 1 shared A. Sorn· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

A. Jairaman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Interruption of the Intratumor CD8:Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy

S. N. Geels, A. Moshensky, R. S. Sousa, B. L. Walker, R. Singh, G. Gutierrez, M. Hwang, T. R. Mempel, Q. Nie, S. Othy, F. Marangoni

This study shows that interrupting CD8:Treg crosstalk during PD-1 immunotherapy improves melanoma control by reducing Treg accumulation.

bioRxiv · May 15, 2023 · PreprintImmunology

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

G. COULIS, D. Jaime, C. Guerrero-Juarez, J. Kastenschmidt, P. Farahat, Q. Nguyen, N. Pervolarakis, K. McLinden, L. Thurlow, S. Movahedi, B. Hughes, J. Duarte, A. Sorn, E. Montoya, I. Mozaffar, , A. Villalta

bioRxiv · Apr 18, 2023Immunology

T Cell Calcium Dynamics Visualized in a Ratiometric tdTomato-GCaMP6f Transgenic Reporter Mouse

T. X. Dong, S. Othy, A. Jairaman, J. Skupsky, A. Zavala, I. Parker, J. L. Dynes, M. D. Cahalan

The paper develops a transgenic Ca2+ reporter mouse to visualize T cell calcium dynamics in vivo and demonstrates localized Ca2+ signaling during migration and receptor engagement.

bioRxiv · Oct 18, 2017Cell Biology

Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

T. X. Dong, S. Othy, M. L. Greenberg, A. Jairaman, C. Akunwafo, S. Leverrier, Y. Yu, I. Parker, J. L. Dynes, Michael D. Cahalan

This study shows that Orai1-mediated Ca2+ signals regulate basal T cell motility by reducing pauses during migration, enhancing cell velocity in confined spaces.

bioRxiv · Apr 19, 2017Immunology