Inhibiting BCKDK in triple-negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity
D. Biswas, L. Slade, L. Duffley, N. Mueller, K. T. Dao, A. Mercer, S. Pakkiriswami, Y. El-Hiani, P. Kieneseberger, T. Pulinilkunnil
This study shows that inhibiting BCKDK in TNBC cells reduces protein translation, impairs mitochondrial function, and enhances doxorubicin-induced cell death.
bioRxiv · May 18, 2021Cancer Biology