Author

A. Mercer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1

Frequent Co-Authors

D. Biswas· 2 shared K. T. Dao· 2 shared L. Duffley· 2 shared N. Snyder-Mackler· 2 shared T. Pulinilkunnil· 2 shared A. Baniel· 1 shared A. Lu· 1 shared A. M. Cowie· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. Biswas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A generalizable epigenetic clock captures aging in two nonhuman primates.

E. A. Goldman, M. M. Watowich, K. L. Chiou, A. Mercer, S. N. Sams, J. E. Horvath, J. Anderson, Cayo Biobank Research Unit, J. Tung, J. P. Higham, L. J. Brent, M. I. Martinez, M. J. Montague, M. L. Platt, K. N. Sterner, N. Snyder-Mackler

This paper develops an epigenetic clock for rhesus macaques using DNA methylation data, achieving high accuracy in predicting age across different populations and species.

bioRxiv · Nov 1, 2022 · PreprintEvolutionary Biology

Impaired hepatic autophagy exacerbates xenobiotics induced liver injury

K. Byrnes, N. T. Bailey, A. Mercer, S. Joshi, G. Liu, X.-M. Yin, B. Khambu

This study shows that impaired hepatic autophagy worsens xenobiotic-induced cholestatic liver injury by promoting p62-Ub-IHB accumulation and suppressing FXR.

bioRxiv · May 27, 2022 · PreprintPharmacology & Toxicology

Maternal effects on early-life gut microbiome maturation in a wild nonhuman primate

A. Baniel, L. Petrullo, A. Mercer, L. Reitsema, S. Sams, J. C. Beehner, T. J. Bergman, N. Snyder-Mackler, A. Lu

This study examines how maternal effects influence gut microbiome maturation in wild gelada infants during their first three years, showing differences in microbial composition between infants of first-time and experienced mothers.

bioRxiv · Nov 6, 2021 · PreprintMicrobiology

Inhibiting BCKDK in triple-negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity

D. Biswas, L. Slade, L. Duffley, N. Mueller, K. T. Dao, A. Mercer, S. Pakkiriswami, Y. El-Hiani, P. Kieneseberger, T. Pulinilkunnil

This study shows that inhibiting BCKDK in TNBC cells reduces protein translation, impairs mitochondrial function, and enhances doxorubicin-induced cell death.

bioRxiv · May 18, 2021Cancer Biology

Silencing branched-chain ketoacid dehydrogenase or treatment with branched-chain ketoacids ex vivo inhibits muscle insulin signaling

D. Biswas, K. T. Dao, A. Mercer, A. M. Cowie, L. Duffley, Y. El Hiani, P. C. Kienesberger, T. Pulinilkunnil

This study shows that BCKAs inhibit muscle insulin signaling and that reducing BCKA levels improves insulin signaling and mitochondrial respiration in skeletal muscle cells.

bioRxiv · Feb 21, 2020 · PreprintCell Biology