Cancer BiologybioRxiv
Inhibiting BCKDK in triple-negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity
D. Biswas, L. Slade, L. Duffley…·T. Pulinilkunnil
This study shows that inhibiting BCKDK in TNBC cells reduces protein translation, impairs mitochondrial function, and enhances doxorubicin-induced cell death.
DOI 10.1038/s41420-021-00602-0