D. Biswas

Organisms use mode-switching to solve the explore-vs-exploit problem

This paper shows that organisms use mode-switching strategies to balance exploration and exploitation based on sensory salience, with implications for robotics.

A dynamic partitioning mechanism polarizes membrane protein distribution

This study identifies a dynamic partitioning mechanism that explains asymmetric membrane protein distribution during signaling events.

Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration

This study shows that surface charge regulation on the plasma membrane integrates signaling networks to control cell polarity and migration through dynamic changes in phospholipid composition.

Presence of sodium taurocholate co-transporting polypeptide and Hepatitis B replication marker on placenta: Another home for the virus

The paper investigates NTCP and HBV replication markers in placental cells, finding NTCP expression and viral markers suggesting placental susceptibility to HBV and potential replication.

Mechanism of glycogen synthase inactivation and interaction with glycogenin

The paper describes the cryo-EM structure of phosphorylated glycogen synthase and its interaction with glycogenin, revealing mechanisms of GS autoinhibition and regulation.

Inhibiting BCKDK in triple-negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity

This study shows that inhibiting BCKDK in TNBC cells reduces protein translation, impairs mitochondrial function, and enhances doxorubicin-induced cell death.

Oncogenic RAS activity predicts response to chemotherapy and outcome in lung adenocarcinoma

This study develops a transcriptional signature to measure RAS pathway activity in lung adenocarcinoma, showing it better predicts chemotherapy response and prognosis than KRAS mutation status.

3D stochastic simulation of chemoattractant-mediated excitability in cells

This paper uses 3D stochastic simulations to model chemoattractant-mediated excitability in cells, showing that noise-driven excitable systems underlie pseudopod formation and migration, with implications for understanding directed cell movement.

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine coronavirus-induced neuroinflammation

This paper investigates the role of MMPs and TIMP-1 in MHV-induced neuroinflammation, showing their involvement in inflammation and potential as therapeutic targets.

Silencing branched-chain ketoacid dehydrogenase or treatment with branched-chain ketoacids ex vivo inhibits muscle insulin signaling

This study shows that BCKAs inhibit muscle insulin signaling and that reducing BCKA levels improves insulin signaling and mitochondrial respiration in skeletal muscle cells.

Prevention of enteric bacterial infections and modulation of gut microbiota composition with conjugated linoleic acids producing Lactobacillus in mice

This study shows that the probiotic Lactobacillus casei strain LC+mcra reduces Salmonella and EHEC infections in mice by modulating gut microbiota composition and improving gut health.

Closed-Loop Control of Active Sensing Movements Regulates Sensory Slip.

This study shows that weakly electric fish use closed-loop control to regulate sensory slip during active sensing movements, maintaining a constant feedback magnitude despite changes in reafferent gain.