Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment
R. Hatae, K. Kyewalabye, A. Yamamichi, T. Chen, S. Phyu, P. Chuntova, T. Nejo, L. S. Levine, M. H. Spitzer, H. Okada
This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.
bioRxiv · Nov 13, 2023Immunology