M. H. Spitzer

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

This study shows that commensal microbes in neonatal skin promote immune homeostasis by regulating monocyte accumulation and IL-17A production by T cells.

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

The paper identifies a novel mechanism of ICI resistance where T cells drive inflammatory resistance via IL-1 and TNF in tumors, with implications for therapy.

The paper identifies a conserved immune recovery trajectory in hospitalized COVID-19 patients through longitudinal mass cytometry analysis, linking immune processes to clinical outcomes.

The paper shows that transient dendritic cell activation during acute infection shapes T cell fate by timing their priming and influencing whether they become effector or memory cells.

The paper uses mass cytometry to identify immune cell signatures in acute ZIKV infection that predict high or low neutralizing antibody titers 6 months post-infection.

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

The paper examines metabolic dynamics in early activated CD8 T cells during the primary immune response, identifying a transient state with maximal glycolytic and oxidative metabolic activity.

The paper defines the systemic immune landscape in response to tumor development across multiple tissues and models, showing dynamic changes and plasticity in the immune macroenvironment.

This study shows B lymphocytes can undergo multiple mitosis-independent divisions after the first mitosis, driven by unique G1 phase characteristics and limited by apoptosis, with Birc5 playing an essential role.

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

The paper screens monoclonal antibodies for cross-reactivity in non-human primates and develops immunophenotyping panels for CyTOF.

The paper compares immunological differences between humans, mice, and non-human primates using CyTOF mass cytometry, identifying species-specific immune responses and correlations with viral serostatus.

The paper profiles immune cell responses in humans to identify sex-specific signaling patterns and provides reference ranges for immune markers.

The paper presents a mass cytometry workflow for standardized immune monitoring in immunotherapy trials, identifying immune cell signatures and validating its robustness across samples and centers.