T. Nejo

IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma

This study shows that delivering IRF8 via retroviral vector reprograms myeloid cells in glioblastoma, enhancing anti-tumor immunity and reducing immunosuppression.

Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

Glioma-neuronal circuit remodeling induces regional immunosuppression

This study shows that glioma-induced neuronal circuit remodeling creates regional immunosuppression in glioblastomas by altering tumor-associated macrophages and T-cell infiltration.

Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

This paper develops a novel transgenic mouse model expressing EGFRvIII-CAR on T-cells to study CAR T-cell therapy in syngeneic glioblastoma models.