Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors
A. M. Chambers, K. B. Lupo, J. Wang, J. Cao, S. Toregrosa-Allen, B. Elzey, S. Pine, S. Jalal, S. Utturkar, N. Atallah Lanman, V. Bernal-Crespo, S. Matosevic
This study engineers natural killer cells to block the CD73-adenosine axis in solid tumors, leading to tumor cell killing and enhanced NK cell activity.
bioRxiv · Oct 5, 2021Immunology