A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates
S. Pons, E. Frapy, Y. Sereme, C. Gaultier, F. Lebreton, A. Kropec, O. Danilchanka, L. Schlemmer, C. Schrimpf, M. Allain, F. Angoulvant, H. Lecuyer, S. Bonacorsi, H. Aschard, H. Sokol, , D. Skurnik
This study uses TnSeq to identify E. coli K1 genes important for meningitis, focusing on PNAG as a vaccine target, showing its efficacy against E. coli and Group B Streptococcus in neonatal models.
bioRxiv · Dec 22, 2022Microbiology