CRISPR-mediated deletion of the Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) improves human T cell function for adoptive T cell therapy
S. Prade, D. Wright, N. Logan, A. R. Teagle, H. J. Stauss, R. Zamoyska
This study shows that deleting PTPN22 in human T cells enhances their cytokine production and anti-tumor activity, suggesting improved function in the tumor microenvironment.
bioRxiv · Dec 3, 2020 · PreprintImmunology