Cancer BiologybioRxivPreprint
Dynamic regulation of hierarchical heterogeneity in Acute Myeloid Leukemia serves as a tumor immunoevasion mechanism
C. Pospori, W. Grey, S. Gonzalez-Anton…·C. L. Lo Celso
The paper shows that hierarchical heterogeneity in AML cells, regulated by immune responses, contributes to disease progression through PDL1 upregulation and dynamic balance between proliferation and immunosuppression.
DOI 10.1101/2020.12.21.414649