Author

A. R. Teagle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. Wright· 2 shared N. Logan· 2 shared R. Zamoyska· 2 shared H. J. Stauss· 1 shared P. Castro-Sanchez· 1 shared R. J. Brownlie· 1 shared R. J. Salmond· 1 shared S. Prade· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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2 shared papersImmunology

D. Wright

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2 papers

Recent·Most cited

ImmunologybioRxivJun 24, 2023

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

A. R. Teagle, P. Castro-Sanchez, R. J. Brownlie…·R. Zamoyska

This study shows that deleting PTPN22 in T cells enhances initial anti-tumor effector function but accelerates T cell exhaustion, with TIM-3 expression linked to IL-2 signaling and NFIL3.

DOI 10.1136/jitc-2023-007614

mouseproteomics

ImmunologybioRxivPreprintDec 3, 2020

CRISPR-mediated deletion of the Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) improves human T cell function for adoptive T cell therapy

S. Prade, D. Wright, N. Logan…·R. Zamoyska

This study shows that deleting PTPN22 in human T cells enhances their cytokine production and anti-tumor activity, suggesting improved function in the tumor microenvironment.

DOI 10.1101/2020.12.03.410043

humanproteomics