D. Wright

CD8 T lymphocytes redeploy embryonic cell cycle control mechanisms to facilitate rapid cell proliferation

This study identifies shared cell cycle control mechanisms between CD8 T cells and embryonic stem cells, revealing similarities in cyclin expression and Emi1 function that support rapid proliferation.

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses

This paper develops a multi-pathogen vaccine targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses, showing strong immunogenicity and protective efficacy in animal models.

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

This study shows that deleting PTPN22 in T cells enhances initial anti-tumor effector function but accelerates T cell exhaustion, with TIM-3 expression linked to IL-2 signaling and NFIL3.

The regulation of methylation on the Z chromosome and the identification of multiple novel Male Hyper-Methylated regions in the chicken

The paper identifies additional male hyper-methylated regions on the chicken Z chromosome and shows trans-effect hotspots influencing methylation across sex and autosomes.

A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

This study shows that mutations in the lncRNA RMRP impair pre-rRNA processing and T cell activation, linking CHH to a ribosomopathy.

Induction of specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination

This study investigates the BCG vaccine's induction of specific antibodies, IgG-secreting plasmablasts, and memory B cells in humans and macaques, highlighting the potential role of humoral immunity in TB vaccine development.

Heterologous vaccination regimens with self-amplifying RNA and Adenoviral COVID vaccines induce robust immune responses in mice

This study shows that heterologous vaccination with self-amplifying RNA and adenoviral SARS-CoV-2 vaccines in mice produces stronger antibody and cellular immune responses than single-dose regimens.

Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substrate-dependent virtual screening

This paper quantifies allosteric communications in MMP1 on alpha-synuclein aggregates using FRET and virtual screening, showing substrate-dependent changes in ligand-binding sites.

CRISPR-mediated deletion of the Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) improves human T cell function for adoptive T cell therapy

This study shows that deleting PTPN22 in human T cells enhances their cytokine production and anti-tumor activity, suggesting improved function in the tumor microenvironment.

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

Inter-domain dynamics and fibrinolytic activity of matrix metalloprotease-1

This study investigates how inter-domain dynamics of MMP1 correlate with its fibrinolytic activity using single-molecule FRET and kinetic modeling.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

Reduced levels of membrane-bound alkaline phosphatase in Vip3Aa-resistant Heliothis virescens

This study investigates resistance to Vip3Aa in Heliothis virescens, finding reduced alkaline phosphatase levels but no direct receptor involvement.

Allosteric communications between domains modulate activity of matrix metalloprotease-1

This paper identifies functionally relevant inter-domain dynamics in MMP1 on collagen fibrils, showing that open conformations correlate with activity and can be modulated by mutations and ligands.

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

Intra-individual behavioural variability: a trait under genetic control

This study identifies genes affecting intra-individual behavioural variability in an avian population using genetical genomics analysis.

Bee visitation and fruit quality in berries under protected cropping vary along the length of polytunnels

The paper examines how bee visitation and fruit quality in berries vary along the length of polytunnels, finding higher pollinator activity and better fruit quality at tunnel ends.

Targeting DNA damage response and Replication Stress in Pancreatic Cancer

The paper identifies novel therapeutic strategies for pancreatic cancer by analyzing DNA damage response and replication stress in patient-derived cell lines.

Structural and Biochemical Studies of Dihydrofolate Reductase from Streptococcus pyogenes as a Target for Antifolate Antibiotics

This study identifies potent DHFR inhibitors against S. pyogenes and determines its crystal structure to guide antifolate antibiotic development.

Characterisation of antigenic MHC Class I-restricted T cell epitopes in the glycoprotein of Ebolavirus

This paper identifies nine T cell epitopes in the Ebolavirus glycoprotein and shows they are presented by multiple HLA alleles, suggesting broad immune recognition.