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S. Raavicharla

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Biophysics· 1

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1

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C. R. Knoverek· 1 shared E. Rennella· 1 shared G. R. Bowman· 1 shared L. E. Kay· 1 shared S. Singh· 1 shared T. E. Frederick· 1 shared T. Yuwen· 1 shared U. L. Mallimadugula· 1 shared

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1 shared paperBiophysics

C. R. Knoverek

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BiophysicsbioRxivApr 14, 2021

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

C. R. Knoverek, U. L. Mallimadugula, S. Singh…·G. R. Bowman

The paper investigates how a cryptic pocket in β-lactamase, formed under the Ω-loop, enhances enzyme activity against penicillin, suggesting excited states can improve function.

DOI 10.1073/pnas.2106473118

protein structureexperimental assay

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