Author

S. Shachar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Assay:imaging· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

T. Misteli· 4 shared G. Pegoraro· 3 shared A. Raznahan· 2 shared D. Wangsa· 2 shared J. L. Russ· 2 shared P. R. Gudla· 2 shared T. Ried· 2 shared Z. M. Jowhar· 2 shared

Activity by Year

2017-2021 · peak 1/yr

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10 top collaborators · 31 mutual co-author links

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4 shared papersCell Biology

T. Misteli

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4 papers

Recent·Most cited

Large-scale mapping of positional changes of hypoxia-responsive genes upon activation

K. Nakayama, S. Shachar, E. H. Finn, H. Sato, A. Hirakawa, T. Misteli

The paper uses high-throughput imaging to analyze the spatial location of hypoxia-responsive genes and finds that their nuclear position changes upon hypoxia but not directly correlated with gene activity.

bioRxiv · Sep 27, 2021 · PreprintCell Biology

A Deep Learning Pipeline for Nucleus Segmentation

G. Zaki, P. R. Gudla, K. Lee, J. Kim, L. Ozbun, S. Shachar, M. Gadkari, S. Jing, I. D. Fraser, L. M. Franco, T. Misteli, G. Pegoraro

This paper develops a deep learning pipeline to evaluate nuclear segmentation models trained on small, custom annotated datasets, showing they can match or exceed performance of pre-trained models.

bioRxiv · Apr 14, 2020Cell Biology

Effects of Human Sex Chromosome Dosage on Spatial Chromosome Organization

Z. M. Jowhar, S. Shachar, P. R. Gudla, D. Wangsa, E. Torres, J. L. Russ, G. Pegoraro, T. Ried, A. Raznahan, T. Misteli

This study investigates how variations in sex chromosome dosage affect chromosome organization in primary cells from SCA patients using HiCTMap imaging.

bioRxiv · Jun 13, 2018Cell Biology

HiCTMap: Detection and Analysis of Chromosome Territory Structure and Position by High-throughput Imaging

Z. M. Jowhar, P. Gudla, S. Shachar, D. Wangsa, J. L. Russ, G. Pegoraro, T. Ried, A. Raznahan, T. Misteli

HiCTMap enables high-throughput imaging and analysis of chromosome territories in mammalian cells, providing precise 2D and 3D positioning and quantification.

bioRxiv · Sep 7, 2017Cell Biology