E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms
M. K. Jolly, K. E. Ware, S. Xu, S. Gilja, S. Shetler, Y. Yang, X. Wang, G. Austin, D. Runyambo, A. J. Hish, S. Bartholf DeWitt, J. T. George, R. T. Kreulen, M.-K. Boss, A. L. Lazarides, , J. A. Somarelli
This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.
bioRxiv · Jan 10, 2019Cancer Biology