Author

D. Sivaraj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Assay:scRNA-seq· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Henn· 5 shared K. Chen· 5 shared M. Januszyk· 5 shared J. Padmanabhan· 4 shared C. A. Bonham· 3 shared G. C. Gurtner· 3 shared J. A. Barrera· 3 shared M. T. Longaker· 3 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersCell Biology

D. Henn

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition

M. Griffin, H. Talbott, N. Guardino, J. Guo, A. Spielman, K. Chen, S. Mascharak, J. Parker, D. Henn, N. Liang, M. King, A. Cotterell, K. Bauer-Rowe, D. Abbas, N. M. D. Deleon, , M. T. Longaker

This study shows that inhibiting Piezo1 or Piezo2 prevents adipocyte-to-fibroblast transition, reducing scarring in wounds and suggesting a therapeutic target for fibrosis.

bioRxiv · Apr 3, 2023 · PreprintCell Biology

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

S. Bartholf DeWitt, S. Hoskinson Plumlee, H. E. Brighton, D. Sivaraj, E. J. Martz, M. Zand, V. Kumar, M. U. Sheth, W. Floyd, J. Spruance, N. Hawkey, S. Varghese, J. Ruan, D. G. Kirsch, J. Somarelli, , W. C. Eward

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology

Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing

D. Henn, D. Zhao, K. Chen, A. Trotsyuk, C. A. Bonham, K. S. Fischer, T. Kehl, T. Fehlmann, D. Sivaraj, A. H. Greco, S. E. Moortgat Illouz, J. Padmanabhan, J. A. Barrera, U. Kneser, H.-P. Lenhof, , G. C. Gurtner

This study uses CRISPR/Cas9 to knockout Ndrg2 in dendritic cells, enhancing their regenerative capacity for wound healing in mouse models.

bioRxiv · Mar 14, 2022Cell Biology

Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

Y. Jiang, A. Trotsyuk, S. Niu, D. Henn, K. Chen, C.-C. Shih, M. Larson, A. Mermin-Bunnell, S. Mittal, J.-C. Lai, A. Saberi, E. Beard, S. Jing, D. Zhong, S. Steele, , Z. Bao

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

bioRxiv · Jan 16, 2022 · PreprintBioengineering

Allometric tissue-scale forces activate mechanoresponsive immune cells to drive pathological foreign body response to biomedical implants

J. Padmanabhan, K. Chen, D. Sivaraj, B. A. Kuehlmann, C. A. Bonham, T. Dohi, D. Henn, Z. A. Stern-Buchbinder, P. A. Than, H. S. Hosseini, J. A. Barrera, H. C. Kussie, N. J. Magbual, M. R. Borrelli, A. A. Trotsyuk, , G. C. Gurtner

The paper shows allometric tissue-scale forces drive pathological foreign body response by activating Rac2 signaling in immune cells, independent of implant properties.

bioRxiv · Jan 14, 2022 · PreprintBioengineering

Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration Through Vitamin D-Activated Trem2+ Macrophages

D. Henn, K. Chen, T. Fehlmann, D. Sivaraj, Z. Maan, C. A. Bonham, J. A. Barrera, C. J. Mays, A. H. Greco, S. E. Moortgat Illouz, J. Q. Lin, D. Foster, J. Padmanabhan, A. Momeni, D. Nguyen, , G. C. Gurtner

The paper shows that vitamin D-activated Trem2+ macrophages promote angiogenesis and reduce fibrosis, offering a new strategy for advanced cell therapies in complex wounds.

bioRxiv · Feb 26, 2021Immunology

A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

J. Somarelli, G. Rupprecht, E. Altunel, E. Flamant, S. R. Rao, D. Sivaraj, A. Lazarides, S. Hoskinson, M. Sheth, S. Cheng, S. Y. Kim, K. Ware, A. Agarwal, M. Cullen, L. Selmic, , D. Hsu

This study develops a cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma, finding that dual inhibition of proteasome and CRM1 pathways induces synergistic cytotoxicity.

bioRxiv · Oct 19, 2020Cancer Biology

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms

M. K. Jolly, K. E. Ware, S. Xu, S. Gilja, S. Shetler, Y. Yang, X. Wang, G. Austin, D. Runyambo, A. J. Hish, S. Bartholf DeWitt, J. T. George, R. T. Kreulen, M.-K. Boss, A. L. Lazarides, , J. A. Somarelli

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

bioRxiv · Jan 10, 2019Cancer Biology