Author

S. Bartholf DeWitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Sivaraj· 2 shared W. C. Eward· 2 shared A. J. Armstrong· 1 shared A. J. Hish· 1 shared A. L. Lazarides· 1 shared B. Alman· 1 shared D. G. Gerber· 1 shared D. G. Kirsch· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

D. Sivaraj

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2 papers

Recent·Most cited

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

S. Bartholf DeWitt, S. Hoskinson Plumlee, H. E. Brighton, D. Sivaraj, E. J. Martz, M. Zand, V. Kumar, M. U. Sheth, W. Floyd, J. Spruance, N. Hawkey, S. Varghese, J. Ruan, D. G. Kirsch, J. Somarelli, , W. C. Eward

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms

M. K. Jolly, K. E. Ware, S. Xu, S. Gilja, S. Shetler, Y. Yang, X. Wang, G. Austin, D. Runyambo, A. J. Hish, S. Bartholf DeWitt, J. T. George, R. T. Kreulen, M.-K. Boss, A. L. Lazarides, , J. A. Somarelli

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

bioRxiv · Jan 10, 2019Cancer Biology