A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response signaling
R. Lawrence, S. Shoemaker, A. Deal, S. Sangwan, A. Anand, L. Wang, S. Marqusee, P. Walter
The paper identifies a Switch-Helix in eIF2B that allosterically regulates ISR signaling and is conserved across species.
bioRxiv · Dec 22, 2022 · PreprintBiochemistry