R. Lawrence

A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response signaling

The paper identifies a Switch-Helix in eIF2B that allosterically regulates ISR signaling and is conserved across species.

Viral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry

This study shows that SFSV NSs protein evades the ISR by competing with eIF2-P for binding to eIF2B, preserving its activity and allowing viral protein synthesis.