A. Anand

Discovering Symbolic Cognitive Models from Human and Animal Behavior

LLM-driven evolutionary program synthesis (CogFunSearch) discovers interpretable Python cognitive models that predict bandit-task choices of humans, rats and fruit flies better than leading hand-designed models.

Asparagine couples group A Streptococcal metabolism to virulence

This study shows that asparagine (Asn) availability regulates Streptococcus pyogenes virulence and metabolism by controlling intracellular ATP levels and CovR/S signaling.

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

Endogenously produced hydrogen cyanide serves as a novel mammalian gasotransmitter

This study identifies endogenous hydrogen cyanide as a novel gasotransmitter in mammals, showing it regulates mitochondrial function and cell metabolism at optimal levels.

Combinatorial characterization of bacterial taxa-driven differences in the microbiome of oyster reefs

The paper characterizes microbial differences in oyster reef ecosystems by analyzing abundance and diversity across soil, biofilm, and oysters in four sites, identifying distinct taxa and their associations with environmental factors.

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties

This study investigates how glioblastoma cells use hyaluronan to support proliferation and resistance, proposing a combination treatment targeting HA synthesis and degradation.

Ultrasound-Assisted Hydrolysis of Food Waste using Glucoamylase: Statistical Optimization and Mechanistic Analysis with Molecular Simulations

This paper optimizes food waste hydrolysis using glucoamylase and sonication, showing improved sugar yield and reaction kinetics through structural and computational analysis.

Genomic plasticity is a blueprint of diversity in Salmonella lineages

This study examines genomic plasticity in Salmonella lineages, revealing non-random integration of pathogenicity genes into regions of genomic plasticity and their regulatory relationships.

Default mode network spatio-temporal electrophysiological signature and causal role in creativity

This study investigates the spatio-temporal electrophysiological patterns of the default mode network (DMN) during creativity and mind wandering, revealing distinct dynamics and causal roles in creative thinking.

Insight into spatial intratumoral genomic evolution in glioblastoma

This study investigates spatial genomic evolution in glioblastoma by comparing hypometabolic and hypermetabolic lesions using genomic and transcriptomic analyses.

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.

A novel, precise and high-throughput technology for viroid detection in cannabis (MFDetectTM)

This paper introduces MFDetectTM, a high-throughput viroid detection method for cannabis, showing it is comparable to RT-PCR and suitable for early HLVd detection in various plant tissues.

Resolving exit strategies of mycobacteria by combining high-pressure freezing with 3D-correlative light and electron microscopy

This paper develops a method to study mycobacteria exit strategies using 3D-correlative light and electron microscopy with improved cell adhesion.

ER-dependent membrane repair of mycobacteria-induced vacuole damage

This study identifies OSBP8 as an ER-dependent lipid transfer protein involved in membrane repair of mycobacteria-induced vacuole damage, which is critical for host defense against M. tuberculosis.

A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response signaling

The paper identifies a Switch-Helix in eIF2B that allosterically regulates ISR signaling and is conserved across species.

The Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP- and Sac1-dependent pathogen vacuole remodeling

Gene expression based inference of drug resistance in cancer

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

Efficient, selectable marker free gene targeting in soybean using novel Ochrobactrum haywardense-mediated delivery

This paper develops a selectable marker-free gene targeting system in soybean using Ochrobactrum haywardense-mediated delivery, achieving 3.4% targeted insertion and 90% mutation rate in T0 plants.

Biological hydrogen cyanide emission globally impacts the physiology of both HCN-emitting and HCN-perceiving Pseudomonas

This study shows that hydrogen cyanide (HCN) emitted by Pseudomonas bacteria globally affects both emitting and receiving strains by modulating traits like motility, biofilm formation, and antimicrobial compound production.

Structural and functional characterization of Rv0792c from Mycobacterium tuberculosis: identifying small molecule inhibitors against GntR protein.

This study characterizes Rv0792c, a GntR homolog from M. tuberculosis, identifies small molecule inhibitors, and reveals its role in stress adaptation and virulence.

Decoding the Neural Signatures of Valence and Arousal From Portable EEG Headset

This study classifies emotions based on valence and arousal using EEG data from a portable headset, achieving specific RMSE scores on benchmark datasets.

Biosynthetic heme of malaria parasite induces cerebral pathogenesis by regulating hemozoin formation and griseofulvin can prevent cerebral malaria

The paper shows biosynthetic heme in malaria parasites promotes cerebral pathogenesis by enhancing hemozoin formation, and griseofulvin prevents cerebral malaria by targeting heme synthesis.

Coordinated action of RTBV and RTSV proteins suppress host RNA silencing machinery

This study shows RTBV ORF-IV suppresses RNA silencing and its activity is enhanced by RTSV proteins, contributing to Tungro disease severity.

Hyaluronic Acid Fuels Pancreatic Cancer Growth

This study shows hyaluronic acid fuels pancreatic cancer metabolism by bypassing GFAT1 via the GlcNAc salvage pathway, enabling proliferation in nutrient-starved conditions.

Characterization of Onion Seedlots into Different Storability Groups with 4 Parameter Hill Function (4-PHF)

The paper uses 4-PHF parameters to classify onion seedlots into storability groups, finding AUC as crucial for accurate categorization beyond conventional germination metrics.

Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses

This paper identifies 29 independently modulated gene sets in S. aureus using ICA, linking them to regulators and physiological responses.

An efficient gene excision system in maize

This paper develops an efficient gene excision system in maize using inducible recombinases to improve transformation and regeneration of fertile plants.

Efficient Gene Targeting in Maize using Inducible CRISPR-Cas9 and Marker-Free Donor Template

This paper demonstrates efficient, marker-free gene targeting in maize using inducible CRISPR-Cas9 and a donor template, achieving high mutation rates and heritable results in the T0 generation.

Organ-on-a-chip model of vascularized human bone marrow niches

This study develops a 3D organ-on-a-chip model of human bone marrow niches that supports hematopoietic stem cell maintenance, differentiation, and myeloid progenitor egress.