S. Shui

Rational design of chemically controlled antibodies and protein therapeutics

This study designs and tests small molecule-controlled switchable protein therapeutics by optimizing protein interactions and demonstrating in vitro and in vivo controllability with Venetoclax.

A rational blueprint for the design of chemically-controlled protein switches

This paper presents a computational strategy to design chemically-controlled protein switches using drug-inhibited interactions, expanding chemical space for synthetic circuits in mammalian cells.