Author

L. Bonati

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

A. Marchand· 1 shared B. Correia· 1 shared C. Parola· 1 shared D. G. Franks· 1 shared D. Kitamura· 1 shared L. Csepregi· 1 shared L. Scheller· 1 shared L. Tang· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBioengineering

A. Marchand

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rational design of chemically controlled antibodies and protein therapeutics

A. Marchand, L. Bonati, S. Shui, L. Scheller, P. Gainza, S. Rosset, S. Georgeon, L. Tang, B. Correia

This study designs and tests small molecule-controlled switchable protein therapeutics by optimizing protein interactions and demonstrating in vitro and in vivo controllability with Venetoclax.

bioRxiv · Dec 22, 2022 · PreprintBioengineering

An Aryl Hydrocarbon Receptor from the Caecilian Gymnopis multiplicata Suggests Low Dioxin Affinity in the Ancestor of All Three Amphibian Orders

S. A. Kazzaz, S. Giana Tagliabue, D. G. Franks, M. S. Denison, M. E. Hahn, L. Bonati, W. H. Powell

This paper identifies a low dioxin-affinity aryl hydrocarbon receptor in the caecilian Gymnopis multiplicata, suggesting this trait evolved in the common ancestor of all amphibians.

bioRxiv · Sep 11, 2019Pharmacology & Toxicology

Molecular design, optimization and genomic integration of chimeric B cell receptors in murine B cells

T. Pesch, L. Bonati, W. Kelton, C. Parola, R. A. Ehling, L. Csepregi, D. Kitamura, S. T. Reddy

The paper designs, optimizes, and genomically integrates chimeric B cell receptors (CBCRs) in murine B cells using CRISPR-Cas9, demonstrating robust surface expression and antigen recognition.

bioRxiv · Jun 5, 2019Immunology