B. Correia

DiffTopo: Fold exploration using coarse grained protein topology representations

This paper introduces DiffTopo, a diffusion model for generating novel protein folds by exploring designable topology space efficiently.

Rational design of chemically controlled antibodies and protein therapeutics

This study designs and tests small molecule-controlled switchable protein therapeutics by optimizing protein interactions and demonstrating in vitro and in vivo controllability with Venetoclax.

A rational blueprint for the design of chemically-controlled protein switches

This paper presents a computational strategy to design chemically-controlled protein switches using drug-inhibited interactions, expanding chemical space for synthetic circuits in mammalian cells.

Immune response to vaccine candidates based on different types of nanoscaffolded RBD domain of the SARS-CoV-2 spike protein

This study evaluates DNA vaccines with RBD domains scaffolded by different peptides, finding that the β-annulus scaffold elicits the strongest immune response in mice.

A bottom-up approach for the de novo design of functional proteins

This paper introduces a bottom-up method for designing functional proteins tailored to complex motifs, demonstrating their use as biosensors and signaling ligands.

De novo protein design enables precise induction of functional antibodies in vivo

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

This study demonstrates that a computationally designed epitope-focused immunogen enhances subdominant neutralizing antibody responses against RSV.