Endosomal trafficking is required for glycosylation and normal maturation of the Alzheimer's-associated protein sorLA
S. K. Christensen, Y. Narimatsu, S. Simoes, C. K. Goth, C. B. Vaegter, S. A. Small, H. Clausen, O. M. Andersen
This study shows that endosomal trafficking is essential for sorLA maturation and shedding, with immature sorLA acquiring complex N-glycans upon retrograde transport.
bioRxiv · Jul 12, 2020 · PreprintCell Biology