Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy
M. Inoue, W. A. Sebastian, S. Sonoda, H. Miyahara, N. Shimizu, H. Shiraishi, M. Maeda, K. Yanagi, T. Kaname, R. Hanada, T. Hanada, K. Ihara
This study identifies biallelic LARS1 variants as a cause of infantile liver failure by showing they induce steatosis via enhanced autophagy in zebrafish.
bioRxiv · Sep 21, 2023 · PreprintCell Biology