M. Maeda

A Novel Method to Visualize Active Small GTPases Unveils Distinct Sites of Sar1 Activation During Collagen Secretion.

The paper introduces SAIYAN, a method to detect small GTPase activation, revealing Sar1 activation at ER exit sites and ERGIC during collagen secretion.

Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy

This study identifies biallelic LARS1 variants as a cause of infantile liver failure by showing they induce steatosis via enhanced autophagy in zebrafish.

Genome Editing Is Induced in a Binary Manner in Single Human Cells

This study uses single-cell isolation to show genome editing in human cells occurs in a binary manner, with all target alleles edited or none edited.

Hydrodynamics of gliding penguin flipper suggests the adjustment of sweepback with swimming speeds

This study uses CFD simulations to analyze how sweepback angles of penguin flippers affect hydrodynamic performance at different swimming speeds.

From wing shape to fluid dynamics in the barn owl (Tyto alba)

This study measures wing shape and pose changes in barn owls during gliding at different speeds, finding that wing shape remains consistent while tail and posture adjustments modulate aerodynamic forces.

Mitotic ER exit site dissociation and reassembly is regulated by TANGO1 phosphorylation status

The paper shows that TANGO1 phosphorylation by CK1 during mitosis disrupts its interaction with Sec16, causing ER exit site dissociation, while a phosphatase PP1 regulates this process.

Comparison of prokaryotic communities among fields exhibiting different disinfestation effects by anaerobic soil disinfestation

The paper compares prokaryotic communities in soils with different disinfestation effects after anaerobic soil disinfestation, finding specific microbial changes associated with effective disinfestation.

Targeted brain tumor radiotherapy using an Auger emitter

A PARP1-targeted Auger radiotherapeutic shows translational potential for imaging and killing cancer cells, resulting in tumor delineation and prolonged survival in a glioblastoma model.

cTAGE5 acts as a Sar1 GTPase regulator for collagen export

This study shows cTAGE5 enhances Sec23's GAP activity toward Sar1 and is necessary for collagen export from the ER.

Remodeling of ER-exit sites initiates a membrane supply pathway forautophagosome biogenesis

The paper identifies a pathway where FIP200 and CTAGE5 remodel ER-exit sites to generate COPII vesicles that contribute to autophagosome biogenesis during starvation.