Author

S. Spence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Joly-Amado· 1 shared A. Kissenpfennig· 1 shared A. Short· 1 shared A. Yakkundi· 1 shared C. Campbell· 1 shared C. Drakeford· 1 shared C. Garciarena· 1 shared D. Sharpe· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Joly-Amado

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2 papers

Recent·Most cited

Lung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice

N. Villalba, Y. Ma, S. A. Gahan, A. Joly-Amado, S. Spence, X. Yang, K. Nash, S. Y. Yuan

This study shows that P. aeruginosa lung infection causes BBB dysfunction and neuroinflammation in mice through cytokine-induced endothelial barrier disruption.

bioRxiv · Jan 23, 2023 · PreprintPharmacology & Toxicology

The immunophilin protein FKBPL and its peptide derivatives are novel regulators of vascular integrity and inflammation via NF-kappaB signaling

S. L. Annett, S. Spence, C. Garciarena, C. Campbell, M. Dennehy, C. Drakeford, J. Lai, J. Dowling, G. Moore, A. Yakkundi, A. Short, D. Sharpe, F. Furlong, J. O'Donnell, G. Cavalleri, , T. Robson

This paper identifies FKBPL and its peptides as regulators of vascular integrity and inflammation via NF-kappaB signaling, showing therapeutic potential in inflammatory diseases.

bioRxiv · Feb 24, 2021 · PreprintImmunology