Author

S. Sureshchandra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Research Focus:differential expression· 7 Approach:experimental assay· 6 Organism:human· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Assay:scRNA-seq· 4 Assay:flow cytometry· 3

Frequent Co-Authors

I. Messaoudi· 9 shared N. E. Marshall· 5 shared A. Jankeel· 4 shared B. Doratt· 4 shared M. Rincon· 4 shared B. M. Doratt· 3 shared N. Mendoza· 3 shared S. A. Lewis· 3 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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9 shared papersImmunology

I. Messaoudi

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Author profile →

9 papers

Recent·Most cited

Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues

B. M. Doratt, S. Sureshchandra, H. True, M. Rincon, N. E. Marshall, I. Messaoudi

This study examines the effects of mild maternal SARS-CoV-2 infection on fetal immune responses, finding altered inflammatory mediators and immune cell activation in cord blood and placental tissues.

bioRxiv · May 10, 2023 · PreprintImmunology

Multimodal profiling of term human decidua reveals tissue-specific immune adaptations with maternal obesity

S. Sureshchandra, B. M. Doratt, N. Mendoza, M. Rincon, N. E. Marshall, I. Messaoudi

The paper constructs an immune cell atlas of term decidua and identifies alterations in immune cell composition and function associated with pregravid maternal obesity.

bioRxiv · Nov 1, 2022 · PreprintImmunology

Impact of pregravid obesity on anti-microbial fetal monocyte response

S. Sureshchandra, B. M. Doratt, N. Mendoza, O. Varlamov, M. Rincon, N. E. Marshall, I. Messaoudi

This study shows that maternal pregravid obesity impairs fetal monocyte responses to bacterial and viral pathogens through epigenetic and signaling defects.

bioRxiv · Jul 10, 2022Immunology

Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

S. Sureshchandra, M. Z. Zulu, B. Doratt, A. Jankeel, D. Tifrea, R. A. Edwards, M. Rincon, N. E. Marshall, I. Messaoudi

This study examines immune changes in pregnant women with mild SARS-CoV-2 infection, finding altered immune responses in blood and decidua that may impact fetal development.

bioRxiv · Aug 23, 2021 · PreprintImmunology

Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defects

S. A. Lewis, B. Doratt, S. Sureshchandra, A. Jankeel, N. Newman, K. A. Grant, I. Messaoudi

This study shows chronic ethanol drinking in rhesus macaques increases inflammatory gene expression and functional defects in alveolar macrophages, linking to increased infection susceptibility.

bioRxiv · Jul 30, 2021 · PreprintImmunology

Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

S. Sureshchandra, S. A. Lewis, B. Doratt, A. Jankeel, I. Ibraim, I. Messaoudi

This study compares the adaptive immune response to SARS-CoV-2 mRNA vaccine and natural infection, finding robust CD4 T and B cell responses but weak and variable CD8 T cell responses.

bioRxiv · Jul 14, 2021Immunology

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking

S. A. Lewis, S. Sureshchandra, B. Doratt, V. Jimenez, C. Stull, K. A. Grant, I. Messaoudi

This study examines how chronic alcohol drinking affects monocytes and macrophages in non-human primates, revealing hyper-inflammatory responses and impaired function.

bioRxiv · May 12, 2021Immunology

Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

S. Sureshchandra, C. N. Chan, J. J. Robino, L. K. Parmelee, M. J. Nash, S. R. Wesolowski, E. M. Pietras, J. E. Friedman, D. Takahashi, W. Shen, J. D. Hennebold, D. Goldman, W. Packwood, J. R. Lindner, C. T. Roberts, , O. Varlamov

This study shows that a maternal Western-style diet impairs fetal bone marrow development and causes hyperinflammation and B-cell dysfunction in fetal hematopoietic stem and progenitor cells in rhesus macaques.

bioRxiv · Apr 26, 2021 · PreprintImmunology

Functional and genomic adaptations of blood monocytes to pregravid obesity during pregnancy

I. Messaoudi, S. Sureshchandra, N. E. Marshall, N. Mendoza, A. Jankeel, M. Z. Zulu

This study examines how pregravid obesity affects immune responses during pregnancy, finding that it disrupts immune activation and promotes immunotolerance.

bioRxiv · Dec 2, 2020Immunology