BiophysicsbioRxiv
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
W. Li, F. R. Ward, K. McClure…·J. Cate
This study identifies how PF-846 selectively stalls ribosome translation by binding in a specific pocket and altering nascent chain path, revealing a mechanism for targeted protein inhibition.
DOI 10.1038/s41594-019-0236-8