BiophysicsbioRxiv
Discrete LAT condensates encode antigen information from single pMHC:TCR binding events
D. B. McAffee, M. K. O'Dair, J. J. Lin…·J. T. Groves
The paper shows that LAT condensates form in response to pMHC:TCR binding events, with condensation probability linked to binding dwell time and a mutation affecting this process.
DOI 10.1038/s41467-022-35093-9