Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma
Z. Li, X. Zhuang, C.-H. Pan, Y. Yan, R. Thummalapalli, J. Hallin, S. Torborg, A. Singhal, J. C. Chang, E. Manchado, L. E. Dow, R. Yaeger, J. G. Christensen, S. W. Lowe, C. M. Rudin, , T. Tammela
This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.
bioRxiv · Sep 29, 2023Cancer Biology