S. W. Lowe

Solid tumor growth depends on an intricate equilibrium of malignant cell states

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas

The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.

Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines

The paper shows hypoxia enhances the inflammatory fibroblast phenotype in pancreatic cancer through HIF-1 activation, promoting tumor progression.

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

This study develops somatic mouse models of gastric cancer that replicate human disease subtypes and reveal genotype-specific metastatic patterns and immune interactions.

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

This study shows that MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer by affecting chromatin modifications and gene expression.

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

A new immunocompetent rectal cancer model to study radiation therapy

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks

The paper identifies host factors required for SARS-CoV-2 and three seasonal coronaviruses using CRISPR screens, revealing shared and virus-specific dependencies.

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition

This study shows that leukemia cell of origin affects apoptotic priming and sensitivity to LSD1 inhibitors, with Evi1 modulating p53 stability and activity.

A rectal cancer model establishes a platform to study individual responses to chemoradiation

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

DNAJB1-PRKACA fusion kinase interacts with β-catenin and liver regenerative response to drive fibrolamellar hepatocellular carcinoma

This study shows that the DNAJB1-PRKACA fusion kinase drives fibrolamellar hepatocellular carcinoma in mice and identifies β-catenin activation and environmental factors as contributors to tumor progression.