Direct reprogramming of the intestinal epithelium by parasitic helminths subverts type 2 immunity
D. Karo-Atar, S. Ouladan, T. Javkar, L. Joumier, M. K. Matheson, S. Merritt, S. Westfall, A. Rochette, M. E. Gentile, G. Fontes, G. J. Fonseca, M. Parisien, L. Diatchenko, J. von Moltke, M. Malleshaiah, , I. L. King
This study shows that helminth infection reprograms intestinal epithelium into a fetal-like state, generating stem cells that inhibit type 2 immunity and promote helminth survival.
bioRxiv · Sep 25, 2021Immunology