Author

I. L. King

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. Fontes· 2 shared A. G. Madrigal· 1 shared A. Gregorieff· 1 shared A. Jardim· 1 shared A. N. Michi· 1 shared A. Rochette· 1 shared A. Sinha· 1 shared C. F. Maurice· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

G. Fontes

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The pharmacopeia of helminth-derived metabolites driving tolerance in dendritic cells

A. N. Michi, N. L. Malacco, J. A. Sandoval, E. Siciliani, A. G. Madrigal, T. Sternlieb, G. Fontes, I. L. King, I. Cestari, A. Jardim, M. M. Stevenson, T. Hunter, F. Lopes

The paper identifies helminth-derived metabolites that reprogram dendritic cells to a tolerogenic phenotype, reducing intestinal inflammation in mice.

bioRxiv · Jan 26, 2023 · PreprintImmunology

Direct reprogramming of the intestinal epithelium by parasitic helminths subverts type 2 immunity

D. Karo-Atar, S. Ouladan, T. Javkar, L. Joumier, M. K. Matheson, S. Merritt, S. Westfall, A. Rochette, M. E. Gentile, G. Fontes, G. J. Fonseca, M. Parisien, L. Diatchenko, J. von Moltke, M. Malleshaiah, , I. L. King

This study shows that helminth infection reprograms intestinal epithelium into a fetal-like state, generating stem cells that inhibit type 2 immunity and promote helminth survival.

bioRxiv · Sep 25, 2021Immunology

Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates severity of DSS-colitis

A. Sinha, Y. Li, M. Khan Mirzaei, M. Shamash, R. Samadfam, I. L. King, C. F. Maurice

This study shows that transplanting bacteriophages from UC patients alters gut bacteria and worsens colitis in mice.

bioRxiv · Sep 10, 2021Microbiology

Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus

J. Downey, H. E. Randolph, E. Pernet, K. A. Tran, S. A. Khader, I. L. King, L. B. Barriero, M. Divangahi

This study shows that mitochondrial cyclophilin D promotes disease tolerance against influenza virus by supporting NK cell development and IL-22 production, reducing lung damage.

bioRxiv · May 28, 2021Immunology

The gut microbiota limits Th2 immunity to Heligmosomoides polygyrus bakeri infection

G. A. Russell, C. Faubert, E. F. Verdu, I. L. King

This study shows that gut microbiota modulate Th2 immunity and tissue granuloma resolution during Heligmosomoides polygyrus bakeri infection, while supporting parasite fitness.

bioRxiv · Jan 30, 2020 · PreprintImmunology