Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice
S. Chowdhury, S. Song, H. E. Zhang, X. M. Wang, M. G. Gall, D. M.-T. Yu, A. J. Lay, M. S.-W. Xiang, K. A. Evans, S. Wetzel, Y. Liu, B. Yau, A. L. Coppage, L. Lo, R. A. Stokes, , M. D. Gorrell
This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.
bioRxiv · Nov 4, 2018 · PreprintPathology