S. Song

Molecular Mechanisms of Quizartinib Resistance in FLT3 Mutants

This study identifies molecular mechanisms of Quizartinib resistance in FLT3 mutants using molecular dynamics simulations and experimental validation, showing distinct electrostatic and hydrophobic effects of D835Y and F691L mutations.

A shared wireless acquisition core for cortical and peripheral recordings in freely moving mice

This paper introduces a wireless headstage for simultaneous cortical, muscle, and movement recordings in freely moving mice, demonstrating its utility in seizure detection and behavior-related neural activity analysis.

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

Role of RANKL in Alveolar Epithelial Cell Regeneration: Potential Novel Contributor to Lung Tissue Repair

This study investigates RANKL's role in lung epithelial cell regeneration, finding it promotes type II alveolar epithelial cell regeneration and may contribute to lung tissue repair.

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

Loss of IRF5 increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

This study shows that loss of IRF5 predicts metastasis and survival in breast cancer and reveals its role in regulating ribosome biogenesis and tumor progression.

CDH1 loss defines distinct diffuse-gastric cancer subtype with T cell exhaustion and EZH2 regulon activation

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

The Mechanism underlying B cell Developmental Dysfunction in Kawasaki Disease Based on Single-cell Transcriptomic Sequencing

This study uses single-cell transcriptomics to identify B cell developmental dysfunction in Kawasaki Disease, showing repression of immune processes and altered gene expression in HSPCs and B cells before treatment.

A burns and COVID-19 shared stress responding gene network deciphers CD1C-CD141- DCs as the key cellular components in septic prognosis

The paper identifies a stress-response gene network linked to CD1C-CD141 dendritic cells that correlates with prognosis in burns and COVID-19.

CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

Naive T lymphocytes chemotax to CCL21 but not to S1P-rich serum

This study shows naive T lymphocytes chemotax to CCL21 but not to S1P-rich serum, using in vitro assays to quantify migration responses.

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

This study identifies PI(3,5)P2 as a regulator of Class I PI3K activity by interacting with its p85 subunit, revealing a feedback mechanism that impacts cancer and tissue repair.

Innate immunity can distinguish beneficial from pathogenic rhizosphere microbiota

The paper shows that plants can distinguish between beneficial and pathogenic Pseudomonas fluorescens strains through distinct immune responses.

An epitope-enriched immunogen increases site targeting in germinal centers

This study shows that an epitope-enriched immunogen preferentially expands RBS-directed antibody responses compared to non-enriched immunogens.

PSKR1 balances the plant growth-defense trade-off in the rhizosphere microbiome

This study shows PSKR1 in Arabidopsis balances growth and defense responses to maintain beneficial rhizosphere microbiome interactions.

On the fitness effects and disease relevance of synonymous mutations

The paper evaluates the fitness effects of synonymous mutations in yeast, refuting claims that they are largely neutral and showing they are often deleterious.

The Arabidopsis D27like1 is a novel Isomerase that Contributes to SL Biosynthesis and Negatively Impacts ABA Level

This paper identifies AtD27-like1 as a cis/cis-{beta}-carotene isomerase that contributes to strigolactone biosynthesis and negatively affects ABA levels in Arabidopsis.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Additive and Dominant Loci Jointly Pyramiding the Grain Quality of Hybrid Rice

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.

Understanding immune-driven brain aging by human brain organoid microphysiological analysis platform

This study develops a human brain organoid microphysiological platform to model immune-driven brain aging by perfusing aged monocytes and observing their effects on organoid tissues.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

Recall of B cell memory depends on relative locations of prime and boost

The study shows that memory B cells form recall germinal centers more effectively when boosts are given at the same site as the initial immunization, leading to higher mutation levels and avidity in BCRs.

Potent antibody immunity to SARS-CoV-2 variants elicited by a third dose of inactivated vaccine

A third dose of inactivated SARS-CoV-2 vaccine significantly enhances plasma neutralization and generates high-affinity anti-RBD memory B cells against variants like Beta, Delta, and Lambda.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Epithelial-mesenchymal plasticity through loss of CTCF motif accessibility and protein expression

The paper investigates chromatin accessibility and CTCF dynamics during reversible EMT/MET, showing CTCF suppression correlates with EMT features and plasticity.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

DELAY OF GERMINATION 6, encoding the ANAC060 transcription factor, inhibits seed dormancy

This study identifies DOG6 as a quantitative trait locus that encodes ANAC060, a transcription factor regulating seed dormancy through its nuclear localization and regulation of phosphatases.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

Escherichia coli Cryptic Prophages Sense Nutrients to Control Persister Cell Resuscitation

The paper shows that cryptic prophages in E. coli regulate phosphate uptake to control persister cell resuscitation, preventing premature resuscitation in nutrient-poor conditions.

Optimized hip-knee-ankle exoskeleton assistance at a range of walking speeds

This study optimizes hip-knee-ankle exoskeleton assistance across walking speeds, finding it reduces metabolic cost by 26-50% but is less effective at slow speeds.