Author

S.-H. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:metagenomics· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

N. Dai· 4 shared S. Arya· 3 shared S. Qi· 3 shared Y. K. Gupta· 3 shared I. R. Correa· 2 shared L. Martinez-Sobrido· 2 shared R. A. Hromas· 2 shared T. Viswanathan· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBiochemistry

N. Dai

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RNase H-based analysis of synthetic mRNA 5-prime cap incorporation

S.-H. Chan, J. M. Whipple, N. Dai, T. M. Kelley, K. Withers, G. Tzertzinis, I. R. Correa, G. B. Robb

The paper describes methods to analyze synthetic mRNA 5' cap incorporation using RNase H-based cleavage and simplified purification techniques.

bioRxiv · Feb 2, 2022Biochemistry

RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro

S. Qi, J. Mota, S.-H. Chan, J. Villarreal, N. Dai, S. Arya, R. A. Hromas, M. K. Rao, I. R. Correa, Y. K. Gupta

This study investigates how the METTL3-METTL14 complex binds and methylates DNA and RNA, revealing distinct preferences for single-stranded DNA and structured RNA.

bioRxiv · Jan 8, 2022Biochemistry

A metal ion orients mRNA to ensure accurate 2'-O ribosyl methylation of the first nucleotide of the SARS-CoV-2 genome

T. Viswanathan, A. Misra, S.-H. Chan, S. Qi, N. Dai, S. Arya, L. Martinez-Sobrido, Y. K. Gupta

The paper reports structures of the SARS-CoV-2 nsp16/nsp10 enzyme complex before and after RNA product release, revealing conformational changes and the role of a metal ion in 2'-O methylation of the first nucleotide.

bioRxiv · Mar 12, 2021Biochemistry

Structural Basis of RNA Cap Modification by SARS-CoV-2 Coronavirus

T. Viswanathan, S. Arya, S.-H. Chan, S. Qi, N. Dai, R. A. Hromas, J.-G. Park, F. Oladunni, L. Martinez-Sobrido, Y. K. Gupta

The paper reports the high-resolution structure of SARS-CoV-2 nsp16/nsp10 complex during mRNA cap methylation, revealing conformational changes and a novel ligand-binding site for antiviral targeting.

bioRxiv · Apr 26, 2020Biophysics