F. Oladunni

The paper validates in vitro human lung tissue models for studying SARS-CoV-2 and influenza virus infections and antiviral treatments.

This study evaluates an inhaled monoclonal antibody against SARS-CoV-2 in hamsters, showing reduced viral burden and lung pathology with low-dose inhalation.

The paper develops an infectious SARS-CoV-2 cDNA clone using a bacterial artificial chromosome, which replicates similarly to the natural virus in cell cultures and animal models.

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

The paper reports the high-resolution structure of SARS-CoV-2 nsp16/nsp10 complex during mRNA cap methylation, revealing conformational changes and a novel ligand-binding site for antiviral targeting.